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People react differently to bed bugs, and individual responses vary with factors including skin type, environment, and the species of bug. This also means the presence of itchy welts cannot be used as the only indicator of a presence. It is possible for an initial infestation within a household to be asymptomatic and go undetected. In some rare cases, allergic reactions to the bites may cause nausea and illness. In a large number of cases, estimated to be fifty percent of all people, there is no visible sign of bites whatsoever, greatly increasing the difficulty of identifying and eradicating infestations. People commonly respond to bed bug infestations and their bites with anxiety, stress, and insomnia. Individuals may also develop skin infections and scars from scratching the bed bug bite locations.

Use of steam or by spraying rubbing alcohol on any visible insects is done to effectively rid bed frames of adult bed bugs and eggs, although it does not serve as a permanent treatment. Small steam cleaners have been very effective for local treatment.

A suspect mattress is sometimes protected by wrapping it in a disposable plastic sheeting, sealing all the seams and putting it on a protected bed after a final visual inspection.

The use of a fabric steamer on the infestations will kill the eggs and the bugs instantly. The bed bugs cannot handle the intense heat and are killed in a couple of seconds. Since steam will penetrate the pores of a mattress, it can reach deep into the corners of beds.

The thermal death point for the common bed bug is 45C (113F), and all stages of life are killed by 7 minutes of exposure to 46C (115F).

There is uncertainty as to how long bed bugs can survive cold temperatures. Below 16.1C (61F), adults enter semi-hibernation and can survive longer. Bed bugs can survive for at least five days at -10C (14F) but will die after 15 minutes of exposure to -32C (-25.6F) Carbon dioxide deployed in the form of "snow" may kill bed bugs by rapid freezing.

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